This white paper comprehensively explains the requirements of the 2019 versions of USP General Chapters and and provides advice on how to put these requirements into practice. These requirements are designed to ensure that any uncertainty in weighing is small or even negligible within the analysis. To avoid this situation, the United States Pharmacopeia (USP) has set stringent requirements for balances that are used to weigh analytes for quantitative assessments. Any error in the weighing step has the potential to propagate through the whole analytical process, causing inaccuracy in the final result. Typically, the weighing of a sample or standard is the first step in the analytical procedure, followed by dilution and subsequent analysis by techniques such as HPLC or qNMR. USP Chapter weighing requirements are mandatory in a Pharmaceutical Quality Control (QC) laboratory, where weighing is a fundamental step in almost every workflow.
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